Puberty suppression is also considered reversible. The medications are discontinued if the adolescent’s GD spontaneously desists. In those cases, the adolescent will undergo normal puberty, albeit a delayed one. However, in cases where GD persists, cross-sex hormones (masculinizing or feminizing, depending on the sex assigned at birth) are first administered at age 16, and gender-reassignment surgery may be performed later, at age 18. In their study, Dr. Annelou de Vries and her colleagues report on 55 young transgender adults, including 22 trans women (male to female) and 33 trans men (female to male) who had puberty suppressed as adolescents. All were assessed three times over six years: before starting puberty suppression, at the time that cross-sex hormones were introduced, and at least one year after gender-reassignment surgery. The researchers assessed psychological adjustment and “measures [of] objective and subjective well-being (often referred to as “quality of life”), that is, the individuals’ social life circumstances and their perceptions of satisfaction with life and happiness.” The study did not address any physical side effects of treatment, although the authors note that those studies are in the works.